9/19/2023 0 Comments Realtimes activateThe amygdala constitutes a core structure of emotion processing ( Phan et al., 2002 Kober et al., 2008). Results are in line with a potential benefit of NF training for amygdala regulation. We present a proof-of-concept study using rt-fMRI-NF for amygdala down-regulation in the presence of aversive scenes. Results of the group whole-brain analyses are discussed. The whole-brain analysis did not detect significant group interactions. Feedback from the amygdala but not from the control region was associated with down-regulation of the right amygdala in the transfer test. Both groups showed down-regulation of the amygdala response during training. The ROI analysis was complemented by an exploratory analysis of activations at the whole-brain level. In a region of interest (ROI) analysis, the VIEW and the REGULATE conditions were contrasted to estimate brain regulation success. In an adjacent run, subjects were presented with aversive pictures without feedback to test for transfer effects of learning. In a control condition, subjects were advised to respond naturally to aversive pictures (VIEW), and a neutral condition served as the non-affective control (NEUTRAL). Subjects completed a one-session rt-fMRI-NF training where they viewed aversive pictures and received continuous visual feedback on brain activation (REGULATE condition). One group of healthy female participants received amygdala feedback ( N = 16) and a control group was presented with feedback from a control region located in the basal ganglia. As a first step, we investigated whether feedback of the amygdala response to aversive scenes can improve down-regulation of amygdala activation. Real-time functional magnetic resonance imaging (rt-fMRI) allows to feedback brain activation and opens the possibility to establish a neurofeedback (NF) training of amygdala activation, e.g., for subjects suffering from emotion dysregulation. Psychiatric conditions of emotion dysregulation are often characterized by difficulties in regulating the activity of limbic regions such as the amygdala. 2Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.1Department Neuroimaging, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.Christian Paret 1,2 *, Rosemarie Kluetsch 2, Matthias Ruf 1, Traute Demirakca 1, Steffen Hoesterey 1, Gabriele Ende 1 † and Christian Schmahl 2 †
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |